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Delta睡眠誘導肽

已更新:6月 2



引用 | EJA報導


Delta sleep-inducing peptide

Abstract Delta 睡眠誘導肽 (DSIP) 是一種天然存在的物質,最初於 1977 年從兔腦中分離出來 [ 1 ]。這種奇怪的物質是一種九肽,通常在下丘腦合成並靶向多個部位,包括腦幹內的一些部位 [ 2 ]。顧名思義,DSIP 促進睡眠,這已在兔、小鼠、大鼠、貓和人類中得到證實 [ 3-5 ]。事實上,DSIP 促進了一種特定類型的睡眠,其特徵是 EEG 的 delta 節律增加。 Delta sleep-inducing peptide (DSIP) is a naturally occurring substance, which was originally isolated from rabbit brain in 1977 [1]. This curious substance is a nonapeptide that is normally synthesized in the hypothalamus and targets multiple sites including some within the brainstem [2]. As its name suggests DSIP promotes sleep and this has been demonstrated in rabbits, mice, rats, cats and human beings [3–5]. In fact DSIP promotes a particular type of sleep which is characterized by an increase in the delta rhythm of the EEG.


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